SIRT2 can participate in metabolic processes, such as adipogenesis, lipid synthesis, gluconeogenesis, glycolysis and glucose uptake, inflammatory response, and oxidative stress, through the regulation of gene expression and cause neurodegeneration, cancer, diabetes, cardiovascular disease, metabolic disorders, etc. It is believed that in-depth research in the future could help us elucidate more molecular mechanisms of SIRT2 between gene expression and metabolic pathways to use it as a potential target for disease treatment and promote its clinical application. Here, SIRT2 is linked to diabetes mellitus.