NFKB1 and dermatomyositis: The pathophysiology of dermatomyositis is thought to include polyclonal B-cell activation, increased immunogenicity of autoantigens secondary to a primary site of inflammation, autophagy with activation of the NF-kB pathway, and a globally increased cytokine response.10 Many such mechanims are involved in the response to ionizing radiation as well,11 and the immune enhancement from radiation therapy might also result in abscopal autoimmune reactions at remote sites.