According to Coregnet ́s analysis, in lung cancer, 21 winning TFs (ZBTB16, ID2, ID4, EPAS1, EGR1, FOSB, HLF, FOXF1, GATA6, GPRASP1, KLF2, MEIS1, MNDA, NR4A3, TAL1, RFX2, RORA, SOX17, PKNOX2, NR2F1, and KLF4) can form a coregulatory network, and nine winning TFs (MYBL2, FOXM1, HOXC6, BZW2, TCF3, SOX4, ETV4, SOX12, and TFAP2C) can form another coregulatory network. The gene discussed is RFX2; the disease is lung cancer.