ZBTB16 is a member of the Krüppel C2H2-type zinc-finger protein family of TFs, which has been found to be upregulated in clear cell renal cell carcinoma, colon cancer, glioblastoma, testicular seminoma, and downregulated in hepatocellular carcinoma, lung cancer, melanoma, pancreatic cancer, prostate cancer, and thyroid carcinoma [53]. This evidence concerns the gene ZBTB16 and lung cancer.