In breast cancer, eight winning TFs (ZBTB16, KLF2, KLF4, NR2F1, EGR1, FOSB, EPAS1, and GPRASP1) can form a coregulatory network, and three other winning TFs (MYBL2, FOXM1, and TAL1) can form another coregulatory network. This evidence concerns the gene KLF4 and breast cancer.