Among these, the isoform NOX2, which is primarily expressed in phagocytes such as macrophages and neutrophils in lungs [16], promotes the uncontrolled generation of ROS implicated in the pathogenesis of several inflammatory disorders, and recent studies have demonstrated that NOX2-ROS signaling in neutrophils promotes TNF-α-induced inflammation in ALI [17]. The gene discussed is CYBB; the disease is acute respiratory distress syndrome.