ITGB2 and severe congenital neutropenia: Anti-CD18 antibodies, another example, were previously shown to reduce neutrophils by only 50% in an endotoxin shock model [48], which could explain why mice treated with anti-CD18 antibodies are not protected against AILI; similarly, CD18-deficient, neutrophil-specific antibody Ly6G or congenital neutropenia did not affect the AILI.