MNDA and related proteins contain a pyrin domain that plays a role in signaling related to programmed cell death and inflammation, and studies have shown that MNDA promotes the degradation of the anti-apoptotic factor MCL-1 and the apoptosis of myeloid cells, and is negatively correlated with the amount of anti-apoptotic proteins MCL-1 and BCL-2 in human CLL samples [27]. This evidence concerns the gene BCL2 and B-cell chronic lymphocytic leukemia.