A recent study in which sacubitril/valsartan was administered to heart failure patients to assess its effects on plasma ANP and urinary cGMP levels showed that, after 2 weeks of treatment, plasma ANP levels had increased approximately 1.5-fold, and there was also an increase in urinary cGMP levels that correlated well with plasma ANP but not BNP [81]. The gene discussed is NPPA; the disease is heart failure.