TGFB1 and colorectal carcinoma: Table 1 lists major autocrine and paracrine interactions between CAF and cancer cells, facilitated by various secretomes, such as growth factors [3,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83]. This unique interaction between cellular components in CRC presents exciting translational potential for clinical use in CRC therapy [84]. Interestingly, autocrine signalling loops such as the canonical WNT and TGF-β pathways have also been reported to be involved in CAF activation that contributes to CRC progression [60].