In addition to clinical overlap, both diseases share features at the molecular level as well; different studies have led to the identification of TDP-43, FUS, SOD1, and dipeptide repeats in C9orf72 as the major aggregating proteins involved in ALS and FTLD patients [6,124,174,175,176,177,178,179]. Here, FUS is linked to amyotrophic lateral sclerosis.