Moreover, in contrast to the upregulated gene sets, GSVA analysis of this gene set also demonstrated a positive correlation with immune cell infiltration and the abundancy of various anti-cancer immune cells (CD8_naive, Tr1, Th2, Th17, Tfh, NKT, MAIT, B cell, NK, γ-δ, CD4_T and CD8_T cells). The gene discussed is CD4; the disease is cancer.