Furthermore, Sorbara et al also showed that cytoinvasive bacteria that are opsonized by C3 prior to infection are targeted by xenophagy, a form of pathogen‐targeted autophagy, due to an interaction between opsonized C3 and the cytosolic protein ATG16L1,22 a key protein involved in the recruitment and targeting of the autophagy machinery. Here, C3 is linked to infection.