IL18 and acute kidney injury: They did find that AKI was associated with mildly significant greater percent increases in urinary YKL-40 (p = 0.03), NGAL (p = 0.02), alpha-1 microglobulin (p = 0.009), and IL-18 (p = 0.03), but no adjustments were performed for baseline differences between those with and without AKI [22].