CD4 and colorectal cancer: As shown in Fig. 5, the expression level of KCNJ14 was positively correlated with CD4 + T cells in both COAD (colon adenocarcinoma) and READ (rectum adenocarcinoma) (P = 3.52e-06, COAD; P = 1.26e-05, READ) and negatively associated with CD8 + T cells in colorectal cancer (P = 2.18e-05, COAD; P = 1.58e-02, READ).