AKT1 and systemic lupus erythematosus: The right module is mainly related to inflammatory response and disease pathways, such as PI3K-AKT signal transduction, Toll-like receptors signal transduction, NF-κB signal transduction, JAK-STAT signal pathway, inflammatory bowel disease, and hepatitis C. The left module is mainly related to immune response pathways, such as systemic lupus erythematosus, autoimmune thyroid disease, and intestinal immune network for IgA production.