Our results provide the first evidence that IL-24 contributes to asthmatic airway remodeling by promoting EMT in bronchial epithelial cells and indicate that IL-37 may improve airway remodeling by abrogating IL-24-mediated EMT by inhibiting p-STAT3 and p-ERK1/2 signaling pathway activation, thereby providing new targets for asthma treatment focused on EMT-related airway remodeling. The gene discussed is IL24; the disease is asthma.