Although many studies have described SIRT3 impairment in LPS-induced ALI, cisplatin-induced AKI, cardiac hypertrophy, Alzheimer’s disease, Parkinson’s disease, and cancers, we found that abdominal surgery under sterile inflammation resulted in SIRT3 deficiency in mesothelial cells22,23,29,39–41. Here, SIRT3 is linked to acute kidney injury.