SIRT3 and early-onset autosomal dominant Alzheimer disease: Although many studies have described SIRT3 impairment in LPS-induced ALI, cisplatin-induced AKI, cardiac hypertrophy, Alzheimer’s disease, Parkinson’s disease, and cancers, we found that abdominal surgery under sterile inflammation resulted in SIRT3 deficiency in mesothelial cells22,23,29,39–41.