In conclusion, while certain other (still to be unveiled) mechanisms of action of SEP-856 may be involved in its clinical efficacy in schizophrenia, the present study sheds further light on the nature of its molecular interactions with TAAR1 and 5-HT1A receptor sites, and supports their likely collective roles in the expression of its antipsychotic and other functional actions. Here, TAAR1 is linked to schizophrenia.