We also found a strong correlation between JAK2-V617F allele burden in granulocytes and the percentages of IL-1R1+ or IL-1RAcP+ HSCs and HSPCs in peripheral blood (Fig. 1c, d, and Supplementary Fig. 2d, e), suggesting that the expression of JAK2-V617F may trigger the expansion of IL-1R1+ or IL-1RAcP+ HSPCs in MPN patients. This evidence concerns the gene IL1R1 and myeloproliferative disorder.