Similar to COVID-19 patient lung tissues (Fig. 1f), the in vivo association between MASP-2 and the SARS-CoV N protein was demonstrated by in situ PLA in the lungs of the Ad-SARS N pre-infected, LPS-challenged mice (Fig. 5b and Supplementary Fig. 4c), and a higher level of the cleaved MASP-2 fragment was also observed in these mice (Supplementary Fig. 4d). The gene discussed is MASP2; the disease is COVID-19.