The second-phase insulin and CP strongly correlate with AUC (I0-30)/AUC (G0-30), AUC (I0-120)/AUC (G0-120), I30, I30/G30, BIGTT-AIR0-30-120 in NGT (online supplemental table 2) and with I0/G0, AUC (I0-30)/AUC (G0-30), BIGTT-AIR0-30-120, I30/G30, first-phase Stumvoll in pre-diabetes (online supplemental table 2). The gene discussed is INS; the disease is diabetes mellitus.