Interestingly, increased FKBP5 mRNA has been reported in postmortem prefrontal cortex samples from an Australian cohort of schizophrenia subjects relative to controls (65), whereas 5-HT2AR density is upregulated in frontal cortex of samples from subjects with schizophrenia (24, 25, 26, 27)—suggesting that certain components of the GR-5-HT2AR pathway are dysregulated within the human disorder. This evidence concerns the gene FKBP5 and schizophrenia.