In the other family, 3 different CRB1 variants were found to be segregating; a great uncle inherited p.Cys195Phe and p.(Ser478ProfsTer24) and developed EOSRD/LCA, and 1 nephew harbored p.(Ser478ProfsTer24) and the in-frame p.(IIe167_Gly169del) and presented with MD. The gene discussed is CRB1; the disease is severe early-childhood-onset retinal dystrophy.