The vitro studies of EAT on the biopsy of patients with type 2 diabetes revealed that the adipokines (activin A, angiopoietin-2, and CD14) secreted by the EAT lowered the Ca2+ flux of cardiomyocytes and the expression of sarcoplasmic endoplasmic reticulum ATPase 2a, and reduced cardiomyocytes shortening of the sarcomere [43]. Here, ANGPT2 is linked to type 2 diabetes mellitus.