We compiled a manually curated senescence-related gene set that encompassed KLRG1, CD57 and other senescence markers (KLRC1, KLRC3, KLRD1, KLRF1, and CD158A) previously shown to be expressed by circulating CD8+ T cells from patients with AML (10) and to be upregulated on senescence-like T cells (27) and on dysfunctional chimeric antigen receptor (CAR) T cells (28). Here, KLRF1 is linked to acute myeloid leukemia.