We found that the IED172 score did not correlate with patient age at diagnosis, 2017 European LeukemiaNet (ELN; https://www.leukemia-net.org/home/) risk category, or mutation count (Supplemental Figure 9, A and B), and that it was higher in AML cases with low leukemia burden (Figure 3, E and F) or in those harboring TP53, RUNX1, ASXL1, and RAS mutations (Figure 3G). This evidence concerns the gene RUNX1 and leukemia.