SPARC and melanoma: The analysis of scRNA-Seq profiles from malignant, immune, and stromal cells isolated from 19 melanoma samples (71), indicated that PI24 genes were predominantly expressed by NK and T cells but also by a cluster of “undefined” cells with fibroblast-associated genes (LGALS1, CALD1, TIMP1, EGR1, and SPARC; Supplemental Figure 28, A–C).