The uniform manifold approximation and projection (UMAP) of single-cell RNA-Seq (scRNA-Seq) data from 8 patients in the Institute for Molecular Medicine Finland (FIMM) AML cohort (30) revealed that naive, central memory and effector memory CD4+ and CD8+ T cells, regulatory T cells, and NK cells were highly enriched in this signature (Supplemental Figure 3, B and C). Here, CD4 is linked to acute myeloid leukemia.