IL6 and oral cavity squamous cell carcinoma: 2014). Increased levels of IL-6 suppressed low LET radiation-induced cell death in oral squamous cell carcinoma (Matsuoka et al. 2016). An increase in exosome concentration was observed in U87MG cells, which have similar size, doubling time, and enzymatic properties as DU145 (Arscott et al. 2013). In the case of studies using low LET radiation, the works cited by us show that the concentration of exosomes increases with increasing dose. We observed an opposite effect for studies using alpha particles (high LET), but it is consistent with previous work (Elbakrawy et al. 2021).