Indeed, when bound to typically nonharmful allergens, allergen-specific IgE can crosslink FcεRI receptors and prompt mast cells and basophils to release inflammatory mediators like histamine, thus eliciting downstream symptoms ranging from a mild itch to anaphylactic shock that is associated with life-threatening hypotension and airway closure (Galli and Tsai, 2012; Kelly and Grayson, 2016; Reber et al., 2017). The gene discussed is IGHE; the disease is anaphylaxis.