TRIM24 and acute leukemia: Ligands for the BRD of TRIM24, which alsobind to the BRD of BRPF1, have been reported by both Palmer et al.46,47 and Bennett et al.48 In addition, a PROTACfor TRIM24 was developed and confirmed TRIM24 as a novel dependencyin acute leukemia.26 At the start of thiswork, there were no reported small molecule ligands for either isoformof TRIM33.