Moreover, a significant level of ATX/lysoPLD release was detected in the culture supernatants of human MCs by Western blot analysis.17 It has already been proven that liver MCs can release various mediators, not only histamine but also heparin, interleukins, cytokines, growth factors, including bFGF, and numerous vasoactive substances.18 Thus, there may be a potential link between liver/biliary MCs and ATX production in the setting of cholestasis. The gene discussed is ENPP2; the disease is cholestasis.