MCs activate protein-activated receptor 2, which leads to TRPV1 sensitization.13 Other than conventional agents used in the control of cholestatic pruritus, such as antihistamines, UDCA, OND, opioids, and serotonin agonists, the pharmacological modulation of upregulated MCs by CROM may have profuse effects on both the pathophysiology of cholestatic pruritus and the lessening of hepatobiliary injury induced by bile duct obstruction. This evidence concerns the gene TRPV1 and cholestasis.