FGF2 and primary biliary cholangitis: They also have important remodeling actions on bile ducts during the progression of PBC and PSC via overexpression of bFGF and histamine.11,12 Histamine has been shown to stimulate biliary growth via autocrine mechanisms, and the MC stabilizer CROM has the ability to induce cholangiocyte apoptosis.1 Thus, many studies so far provide evidence that MCs may be a therapeutic target for the treatment of cholangiopathies.