TNFSF13B and Graves disease: In the present study, we found that the pathological progression of GD was prolonged and exacerbated by positive feedback regulation of abnormal differentiation of local autoimmune secretory B cells (ASCs) in the thyroid induced by high TH levels, in which BAFF plays a key bridging role and can be considered as a potential target for local thyroid immunosuppression in the treatment of Graves' hyperthyroidism relapse.