The inclusion of NT-proBNP to the multivariable adjusted model did not alter results substantially, nor did the further inclusion of elevated PAC counts (HR 1.9, 95% CI 1.2–2.8; P = .005 for AF and HR 2.9, 95% CI 1.3–6.5; P = .008 for HF). The gene discussed is NPPB; the disease is atrial fibrillation.