By analyzing the data from TCGA, performing immunohistochemistry (IHC) and Real‐time PCR assays, a negative correlation between RNF43 and CD163, which was one of the most widely used TAM‐specific biomarkers, was observed in ccRCC samples (Figure 1A‐D). The gene discussed is RNF43; the disease is nonpapillary renal cell carcinoma.