Subsequent co-immunofluorescent studies on infected, whole-mounted HNSCC slice cultures demonstrated that a substantial amount of N+ve infected cells also expressed active caspase 3 (aCas3), implying that VSV-GP-GFP can induce apoptosis in patient-derived HNSCC slice cultures (Fig. 5D–F). The gene discussed is CASP3; the disease is head and neck squamous cell carcinoma.