AOPEP and early-onset autosomal dominant Alzheimer disease: Carrying the most deleterious Apo-ε4/ε4 haplotype instead of the most common Apo-ε3/ε3 resulted in 2.48 (CI 2.28–2.68) attributable DALYs, mainly through an increase in the risk of Alzheimer’s disease and other dementias (HR = 5.97, CI 5.57–6.40; Fig. 2e).