The five most impactful genes (Fig. 3 and Supplementary Tables 7–9) were LDLR (ischemic heart disease), BRCA2 (breast, ovarian, liver and prostate cancer, and COPD), MYBPC3 (cardiomyopathy and myocarditis), BRCA1 (breast and ovarian cancer) and MLH1 (colon and rectum cancer). This evidence concerns the gene MLH1 and rectal cancer.