Most common variants with the largest effects on DALYs affected ischemic heart disease risk (for example, rs3798220, LPA; rs11591147, PCSK9; and rs1537371, CDKN2B-CDKN2A) and some affected risk of dementia (rs429358, APOE), prostate cancer (rs183373024, POU5F1B) or type 2 diabetes (rs117361510, JPH2). The gene discussed is APOE; the disease is dementia.