BRCA1 and breast cancer: As an example, individuals carrying one pLOF in BRCA1 lose on average 4.08 (CI 2.74–6.32, P = 1.4 × 10−5) healthy life years through breast cancer (2.11 DALYs, CI 1.39–3.14; HR = 7.01, CI 4.94–9.94) and ovarian cancer (1.97 DALYs, CI 0.95–3.93; HR = 16.2, CI 8.22–31.8).