Of the 15 genes neighboring the DMRs, a substantial fraction is involved in energy metabolism (PARP6 and AGPAT3), transcriptional and epigenetic regulation (TCF3 and BCOR) and associated either directly or indirectly to inherited syndromes causing lipodystrophy, hypotonia and intellectual and heart disorders (C5orf58, AGPAT3, DNAJC19 and HCN4). The gene discussed is PARP6; the disease is lipodystrophy.