Patel GK’s team found that CAF-derived exosomes in PC are rich in microRNA106B and can transfer microRNA106B into PC cells through exosomes, thereby reducing the tumor protein p53 inducible nuclear protein 1 (TP53INP1) protein level in PC cells and inducing GEM resistance in tumor cells[62]. Here, TP53INP1 is linked to pachyonychia congenita.