The study of Wei Q’s team using exosome-EphA2 + CA19-9 + carbohydrate antigen 242(CA242) as an early diagnostic marker for PC showed that the combination of exosome-EphA2 + CA19-9 + CA242 can improve not only the ability for early diagnosis of PC but also the ability to distinguish between PC and benign pancreatic diseases[85]. This evidence concerns the gene EPHA2 and pachyonychia congenita.