MicroRNA-5703 transferred in PSC-derived exosomes can also target chemokine-like factor (CKLF) like MARVEL transmembrane domain containing 4 (CMTM4) expression in PC cells, downregulating its expression and subsequently upregulating p21 (RAC1) activated kinase 4(PAK4) expression, in turn activating the PI3K/AKT signalling pathway to promote cell proliferation [50]. This evidence concerns the gene CKLF and pachyonychia congenita.