ESRRA and familial dilated cardiomyopathy: The observed up-regulation of AKT and ERK1/2 signaling as well as phosphorylation of Cofilin 1 at S3 upon dual inhibition of ErbB2 and ERRα signaling is an indication of profound cardiac remodeling and deregulated sarcomeric structure and function, underlying features of the aggravated DCM pathogenesis in KI:KO mice.