The ErbB2 KI-driven signature, harboring the least molecules, showed less modulated pathways underscored by phosphoprotein- and/or gene-level changes including perturbed phosphorylation of sarcomeric Myl2 and Tnni3 proteins associated with ILK, PKA and/or DCM signaling and deregulated expression of several growth factors (e.g., Fgf6/16, Igf1, Pgf). Here, MYL2 is linked to familial dilated cardiomyopathy.