C5 and coronary artery disorder: For example, in CHIP-associated CpG cg14594111, increased DNAm was causally associated with reduced CAD risk (Fig. 3), and the mQTL associated with cg14594111 were also cis-eQTL associated with reduced expression of nearby genes including C5, CNTRL, GSN, PHF19, and RAB14 (Supplementary Data 8).