DNMT3A CHIP is associated with reduced DNAm in cg17969560, whose mQTL instruments are correlated with increased expression of LTBP3 and NEAT1. LTBP3 is implicated in development of aortic aneurysms and dissections57–59, whereas NEAT1 is implicated in inflammation and atherosclerosis60–62. The gene discussed is LTBP3; the disease is aortic aneurysm.