The 200-bp regions surrounding replicated CpGs associated with DNMT3A CHIP were enriched for 40 motifs (FDR < 0.001; Supplementary Fig. 7), including RUNX1 and RUNX2 with roles in HSC and osteoblastic differentiation, five members of the GATA subfamily of transcription factors with roles in development and self-renewal, and five members of the Homeobox family including HOXA9 with roles in AML. Here, RUNX1 is linked to acute myeloid leukemia.