This directional consistency led to correlation between DNMT3A CHIP and DNMT3A AML test statistics (r = 0.29; Fig. 2e) and TET2 CHIP and TET2 AML test statistics (r = 0.33; Fig. 2f); comparable correlations were not observed between DNMT3A CHIP test statistics and TET2 AML test statistics (r = 0.10) or vice versa (r = 0.04). Here, DNMT3A is linked to acute myeloid leukemia.