Immunofluorescence analysis of tumor sections demonstrated that p-SHP2 Try542, p-ERK, and CHOP expression were strikingly increased, accompanied by moderately increased TUNEL staining in elaiophylin-treated xenografts compared with the other groups (Fig. 7j–l and Supplementary Fig. S17), suggesting that elaiophylin fully activated the SHP2/MAPK pathway and induced ER stress in chemotherapy- and PARPi-resistant tumors. The gene discussed is DDIT3; the disease is neoplasm.