In APS, IL-1Ra was the most abundant protein (103,000 ± 50,000 pg/mL), followed by IGF-1 (93,000 ± 17,000 pg/mL), and TGF-β1(15,000 ± 8000 pg/mL). This evidence concerns the gene TGFB1 and autoimmune polyendocrinopathy.