Salivary ORM1 was significantly elevated in patients with advanced liver cancer compared to patients with early liver cancer, and in patients with tumors larger than 3 cm in diameter compared to patients with tumors less than 3 cm in diameter.Elevated salivary ORM1 may be a risk factor for poor prognosis in HCC patients.Although there have been studies on salivary proteomics of liver cancer, this study involved studies on salivary markers of liver cancer, liver cirrhosis, hepatitis B and healthy people, and finally found different salivary markers of liver cancer19. This evidence concerns the gene ORM1 and hepatocellular carcinoma.