AFP and hepatocellular carcinoma: The expression levels of ORM1 in saliva of HCC patients with metastasis were higher than those of HCC patients without metastasis (p = 0.261) (Fig. 4e).The expression levels of AFP in saliva of HCC patients with metastasis were significantly higher than those of HCC patients without metastasis (p = 0.001) (Fig. 4f).