There was no statistically significant difference in salivary ORM1 between BCLC 0 and BCLC A, nor between BCLC stage B, C and D. The expression levels of ORM1 and AFP in saliva of HCC patients with the largest tumor diameter > 3 cm were significantly higher than those of HCC patients with the largest tumor diameter ≤ 3 cm (ORM1:p = 0.0128,AFP:p < 0.001) (Fig. 4c and d). Here, ORM1 is linked to hepatocellular carcinoma.