The level of salivary AFP was significantly higher in the early HCC group than in the non-HCC group (LC: p = 0.001,CHB:p = 0.038,NC: p < 0.001) (Fig. 3d).The level of salivary ORM1 was significantly higher in the early HCC group than in the non-HCC group(LC: p < 0.001,CHB: p = 0.004,NC: p < 0.001) (Fig. 3e). The gene discussed is ORM1; the disease is hepatocellular carcinoma.