In addition, some reports have pointed out that highly metastatic and malignant cancers frequently over generate heparanase-1, which can degrade HSPGs in the tumor microenvironment, causing enhanced secretion of the above bioactive factors and the consecutive triggering of related pathways resulting in cancer metastasis, epithelial-mesenchymal transition, and neovascularization. Here, HPSE is linked to neoplasm.