Introduction: Histiocytosis-Lymphadenopathy (HL) plus syndrome is caused by biallelic mutation of SLC29A3 gene encoding ENT3, a nucleoside transporter largely expressed on the outer mitochondrial membrane and lysosomal membrane of different cells, including monocytes/macrophages, glial cells, ocular and inner ear cells and epithelial cells. This evidence concerns the gene SLC29A3 and Hodgkins lymphoma.