The genetic analysis detected at least one variant in 11 (26.1%) children, 5 (45.4%) with cSLE (ADAR, TNFAIP3, RNASEH2B, SHOC2, IFIH1) and 6 (54.5%) with lupus-like phenotype (TREX, DNASE1,RNASEH2B, C1S, TLR7, STAT5A, TNFRSF13B). The gene discussed is TNFAIP3; the disease is systemic lupus erythematosus.