ESR 60 mm/hr, CRP 23.4 mildly raised, LFT normal, U/E/C normal, LDH 187,ENA ( Ro/SS-A 52, Ro/SS-A 60 and La/SS reacted +ve), D-dimer normal, PT APTT INR normal, ANA +ve, antids- DNA neg,anticardiolipin IgG& IgM neg, anti phospholipid IgG&IgM neg, lupus anticoagulant weak +ve, C3&C4 normal range, coomb’s test normal. The gene discussed is BTG3; the disease is systemic lupus erythematosus.