Furthermore, correlation has been investigated between duration of symptoms and the following clinical and biochemical features at chorea onset: age, throat culture positivity for streptococcus, presence of hemichorea, psychiatric symptoms, carditis and/or arthritis, reactive C protein (RCP), erythrocyte sedimentation rate (ESR) and anti-streptolysin-O (ASO) titer. The gene discussed is CRP; the disease is arthritic joint disease.