Another explanation for the difference in Lkb1-mediated host response to LTA and Spneu could be a role of non-myeloid cells (not affected in Stk11-ΔM mice), considering that mice with a global TLR2 deficiency showed a reduced neutrophil influx during pneumococcal pneumonia [23]; airway epithelial cells may play a role in this context [33, 34]. The gene discussed is TLR2; the disease is pneumococcal pneumonia.