Furthermore, others have found hsa-miR-205 binding sites in the noncoding region of the Zinc Finger E-Box Binding Homeobox 1 (Zeb1) and Smad interacting protein 1 (Sip1) mRNA sequences, two key proteins, which have been implicated in epithelial–mesenchymal transition (EMT) and suggesting a potential role for DCIS to invasive breast cancer cell transition/progression [81]. The gene discussed is ZEB1; the disease is ductal breast carcinoma in situ.