However, recent studies have challenged the causal relationship between eosinophilic airway inflammation and cough in asthmatics [40, 41], such as the failure of anti-interleukin (IL)-5 antibody to modify the cough of severe asthma [41], and the possibility for a role of activated mast cells in cough rather than eosinophilic airway inflammation [42, 43]. The gene discussed is IL5; the disease is asthma.