DNM1L and ischemia: The elimination of damaged mitochondria following ischemic stroke is crucial for recovery (Lan et al., 2018) and it is activated through several mechanisms, which include ischemia-induced mPTP opening, mitochondrial membrane potential disruption (Reichert et al., 2001; Wang et al., 2012), ROS elevation (Wang et al., 2012; Fan et al., 2019), and Drp1-mediated activation (Zuo et al., 2014).