While soluble Aβ(1-42) oligomers rather than fibrils have been proposed to drive the main toxic events in AD pathology, 17βHSD10 also has a higher affinity for binding Aβ(1-42) as compared with Aβ(1–40) (Chen et al., 2017; De et al., 2019; Ciudad et al., 2020) and the affinity is determined by the oligomerization of the peptide (Hemmerová et al., 2019). The gene discussed is HSD17B10; the disease is Alzheimer disease.