PIK3CA and colonic neoplasm: This somatic variant is also recorded in the COSMIC database from colon tumor samples under the legacy identifier of COSM776, and reported to be associated with 27 submitted interpretations and evidence in the ClinVar database [71], including PIK3CA-related overgrowth spectrum (ClinVar accession: RCV000201235.1), breast adenocarcinoma (ClinVar accession: RCV000014629.5), and pancreatic adenocarcinoma (ClinVar accession: RCV000417557.1).