An increase in 10 total protozoal infections from birth to 2 years was associated with a 60% increase in PP (0.60; 95% CI, 0.06–1.14) and an almost one third decrease in ApoA-I (–0.29; 95% CI, –0.55 to –0.03), as well as a notable increase in insulin concentration and a decrease in sCD40L, although the latter two have CIs that narrowly included the null value. Here, CD40LG is linked to protozoa infectious disease.