CPV2 is characterized by tropism in the footpad region, with the presence ofendophytic papillomas, and has been found in dogs from Germany, Japan and the USA.In addition to CPV2, CPV12 was also found in footpad lesions in dogs from the USA,and other CPV types were identified in endophytic papillomas of dogs from differentcountries: CPV1 in Italy; and CPV6 in Switzerland and Taiwan (Table 3). The gene discussed is CYP19A1; the disease is papilloma.