We also identified 12 novel non-DDR predisposition genes (ADGRG1, CHD4, DNMT3A, ERBB3, GRHL1, HMBS, LDLR, MYH7, MYO6, NT5C2, NUP98 and SUGCT), which have not been previously reported in prostate cancer patients in all ethnic groups (S3 and S4 Tables). The gene discussed is HMBS; the disease is Familial prostate cancer.