Two novel predisposition gene MYH7 and LDLR belong to the ACMG published recommendations for reporting secondary findings in clinical exome and genome sequencing (ACMG SF v2.0)[22] (N = 59) (S1 Table) while DNMT3A, CHD4, ERBB3, NT5C2, and NUP98 belong to the panel of 716 cancer driver genes from TCGA and ICGC identified by the platform OncoVar [46] (S2 Table). Here, CHD4 is linked to cancer.